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Altace is used for the treatment of heart failure (congestive heart failure or CHF) and high blood pressure (hypertension). Treatment also prevents heart attacks, strokes and deaths due to heart disease. Altace slows the progression of kidney failure in patients with diabetes.
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Altace norvasc combination therapy (TTC) for rheumatoid arthritis. It was a randomized, buy altace baikal-pharmacy com double-blind, placebo-controlled trial (NCT01182791). The main outcome measures were a measure of joint space narrowing (JSS), and a measure of the percentage total joint space occupied by the cartilage (JPS). Rheumatoid arthritis is the most common chronic inflammatory disease of joints in the Western world and, at last count, affects approximately 4.7 million people in the U.S. alone. It is characterized by the onset of joint pain, stiffness, and tenderness, often associated with radiculopathy (joint inflammation) and osteoarthritis (inflammation of the bones). It is also associated with increased risk of death and complications related to joint disease. The mechanism of action treatment is unclear, but may involve both anti-inflammatory and anti-arthritic effects, with the latter being mediated by effects on cartilage. The primary objective of study was to evaluate the safety of TTC in patients with rheumatoid arthritis compared to placebo. Secondary objective was the assessment of efficacy TTC in improving JSS and JPS. A total of 100 patients were randomized to receive 1) 100,000 IU of TTC for 5 consecutive days, or 2) placebo. The primary endpoint was change in JSS after treatment. Secondary endpoints were evaluation of clinical efficacy: the change in JSS, percentage of cartilage that was occupied by cartilage, as well changes in clinical activity. Data from the Altace 120 Pills 5mg $199 - $1.66 Per pill primary outcome measure were analyzed using a paired t test. The investigators found that, on average, the change in JSS after treatment was 9.5% for the TTC group compared to 5.8% for the placebo group. change in percentage of cartilage occupied by was 5.7% for the TTC vs. 3.9% placebo group. The study also found that change in JSS and JPS did not differ between the two groups. The study concluded that treatment with TTC can result in a reduction the JSS and JPS. "It is important to note that the safety profile of TTC in rheumatoid arthritis is consistent with the Betametasona 8 mg inyectable precio farmacia guadalajara findings of previous studies on the use of this drug in population," said the authors. "We also observed that the effect of treatment was dose-dependent and that the majority of patients who took TTC in the course of study had a favorable outcome." This study was supported by the National Institute of Arthritis and Musculoskeletal Skin Diseases, by the National Institute of Arthritis and Musculoskeletal Skin Diseases, Department of Veterans Affairs, and by the National Institutes of Health R01 AR060159. Dr. Siegel, Kwon, and Hwang did all of the work on study. Dr. Siegel's was supported by an Arthritis Research and Technology Award from the United States Department of Veterans Affairs and an Arthritis Research Technology Award from the National Center for Research Resources. Dr. Hwang's work was supported by a National Institutes of Health Training Grant (T32 AR065006). Dr. Kwon's work was supported by the Arthritis Foundation. Dr. Lee's work was supported by the Arthritis Foundation. Commenting on the study, Barbara R. Siegel, MD, PhD, Director of the University Chicago Department Medicine, commented, "Despite some limitations, this study is an important first step in demonstrating the potential benefits of TTC in individuals with rheumatoid arthritis." She added that "the study also confirms the effectiveness of this drug in improving joint space narrowing rheumatoid arthritis. This is particularly encouraging, given that it is one of the most common complaints experienced by patients with rheumatoid arthritis." "Although this study included only a relatively small sample of patients with rheumatoid arthritis, it provides preliminary evidence of the efficacy TTC in reducing progression of joint space narrowing in patients with rheumatoid arthritis," said H. Michael Kwon, MD, MSc, the David H. Koch Professor of Arthritis and Co-Director the Center for Arthritis and Rheumatology at the University of Colorado School Medicine. "The results of this study, along with those from past studies involving a smaller number of patients, suggest that the beneficial effects of TTC in reducing the progression of joint space narrowing in patients with rheumatoid arthritis may be even greater." Dr. Siegel and Kwon concluded that the results of this trial warrant "a full-scale, multicenter, placebo-controlled, double-blinded clinical trial" to confirm the efficacy of TTC in patients with rheumatoid arthritis. Commenting on the study, Dr. Hwang noted importance of this finding, adding, "Because the"
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